Proof-of-concept study: APOE4 brain endothelial cells as a phenotypic compound screen

Overall, our data supports the potential of our in vitro screen to identify compounds that prevent LPS-induced dysfunction in APOE4 brain endothelial cells.

Authors

Institutions

Publication Details

Journal
Alzheimer s Research & Therapy
Published
2026-02-01
DOI
https://doi.org/10.1186/s13195-026-01960-6
Primary Topic
Barrier Structure and Function Studies
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Proof-of-concept study: APOE4 brain endothelial cells as a phenotypic compound screen

Felecia M Marottoli, Gregory RJ Thatcher, Ana C. Valencia-Olvera, Kiira Ratia et al.
Alzheimer s Research & Therapy
Barrier Structure and Function Studies
article

Proof-of-concept study: APOE4 brain endothelial cells as a phenotypic compound screen

Felecia M Marottoli, Gregory RJ Thatcher, Ana C. Valencia-Olvera, Kiira Ratia, Leon Maing Tai
article en

Abstract

Overall, our data supports the potential of our in vitro screen to identify compounds that prevent LPS-induced dysfunction in APOE4 brain endothelial cells.

Alzheimer s Research & TherapyVol. 18(1)
University of Arizona (US), University of Illinois Chicago (US)
Openalex Percentile: Top 75%
Barrier Structure and Function Studies
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Proof-of-concept study: APOE4 brain endothelial cells as a phenotypic compound screen — Felecia M Marottoli, Gregory RJ Thatcher, et al. · Alzheimer s Research & Therapy (2026) | TGRS Research Map | TGRS