Elevating Circulating L‐Kynurenine Promotes Frailty in Aging Mice
We conclude that PGC1α overexpression in skeletal muscle mitigates the exacerbation of physical frailty induced by elevated circulating L-Kyn in aging mice, in part through increased skeletal muscle capacity for L-Kyn metabolism due to PGC1α-induced increase in muscle KAT expression.
Authors
- Abigail L. Tice
- Mia Y. Kawaida
- Samuel Alvarez
- Terence E. Ryan
- Jacob A. Lackey
- Russell T. Hepple
- Benjamin Izaguirre
- Qingping Yang
- Lan Wei‐LaPierre
Institutions
- University of Florida Health (US)
- University of Florida (US)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/jcsm.70214
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00