Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease
Preclinical data demonstrating that luspatercept mitigates vaso-occlusive and anemia-related complications in the Townes sickle cell model provide a strong rationale for its evaluation in SCD patients.
Authors
- Zhihong Wang
- Jie Bai
- Justin G. Horowitz
- Tian Li
- Gang Huang
- Mingzhe Pan
- Julia Z. Xu
- Maiko Sezaki
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- Urology San Antonio (US)
- Fujian Provincial Hospital (CN)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1172/jci197706
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- National Institutes of Health