Effects of topological domain disruption on transcriptional regulation are chromatin context dependent
CTCF-dependent boundary integrity at the NOTCH1 locus tunes transcriptional output and cellular phenotypes in a chromatin context-dependent manner, supporting a model in which conserved 3D architecture constrains regulatory communication but yields distinct outcomes across cellular states.
Authors
- Diana Itzé Mojica-Santamaría
- Gustavo Tapia-Urzúa
- Rodrigo Gacel Arzate-Mejía
- Georgina Guerrero
- Carlos Alberto Peralta-Alvarez
- Ángel Josué Cerecedo-Castillo
- Félix Recillas-Targa
- Hober Nelson Núñez-Martínez
Institutions
- University of Zurich (CH)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1186/s13072-026-00660-7
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00