Integrative Single-Cell and Spatial Transcriptomic Analysis Reveals MAIT Cell Dysfunction in Relapsed HCC
Relapsed HCC is characterized by enhanced malignant hepatocyte stemness and altered MAIT cell states within the tumor microenvironment. These findings suggest an association between MAIT cell dysregulation and relapse-specific tumor biology, warranting further functional investigation.
Authors
- Sook‑Hyang Jeong
- Hayoung Jang
- Chang Jin Yoon
- Hyun Seok Kim
- Jin‑Wook Kim
- Thuy Nguyen-Phuong
- Gwang Hyeon Choi
- Hyunsung Nam
- Geon Woo Park
- Jae Hwan Lee
- Chung-Gyu Park
Institutions
- Seoul National University (KR)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- Io Therapeutics (United States) (US)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jhc.s575861
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Seoul National University Bundang Hospital
- National Research Foundation
- Seoul National University
- Korea Health Industry Development Institute
- Ministry of Science and ICT, South Korea
- Advanced Research Projects Agency
- College of Medicine, Seoul National University
- Institute for Information and Communications Technology Promotion