A Pharmacist-Driven Closed-Loop Stewardship Model of Meropenem: Impact on Stability and Efficacy in Neurosurgery Patients

The closed-loop stewardship model effectively improved meropenem target concentration attainment by systematically reducing drug loss through degradation and metabolism. This optimized exposure profile correlated with improved eradication rates of Gram-negative sensitive bacteria.

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Publication Details

Journal
Drug Design Development and Therapy
Published
2026-02-01
DOI
https://doi.org/10.2147/dddt.s569180
Primary Topic
Antibiotics Pharmacokinetics and Efficacy
Type
article
Field-Weighted Citation Impact
0.00

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article

A Pharmacist-Driven Closed-Loop Stewardship Model of Meropenem: Impact on Stability and Efficacy in Neurosurgery Patients

Peng Deng, Jinhong Qian, Jinhui Xu, Yanxia Yu et al.
Drug Design Development and Therapy
Antibiotics Pharmacokinetics and Efficacy
article

A Pharmacist-Driven Closed-Loop Stewardship Model of Meropenem: Impact on Stability and Efficacy in Neurosurgery Patients

Peng Deng, Jinhong Qian, Jinhui Xu, Yanxia Yu, Chunmeng Xue, XiangLong Chen, Shenjia Huang, Lijuan Yang, Lian Tang, Tongtong Li, Mian Ma, Qian Zhang
article en

Abstract

The closed-loop stewardship model effectively improved meropenem target concentration attainment by systematically reducing drug loss through degradation and metabolism. This optimized exposure profile correlated with improved eradication rates of Gram-negative sensitive bacteria.

Drug Design Development and TherapyVol. Volume 20
Suzhou Municipal Hospital (CN), Nanjing Medical University (CN)
Jiangsu Pharmaceutical Association, Nanjing Medical University
Good health and well-being
Openalex Percentile: Top 70%
Antibiotics Pharmacokinetics and Efficacy
DOIOpen Access PDFOpenAlex
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