A multicentre randomized double-blind placebo-controlled study of lacosamide, pregabalin, and tapentadol on spinal pain biomarkers

Our findings support the RIII threshold as an objective spinal biomarker to assess antihyperalgesic drug effect. This study informs future choices of biomarkers, optimal timing, and analysis strategies in analgesic research.

Authors

Institutions

Publication Details

Journal
Clinical Neurophysiology
Published
2026-02-01
DOI
https://doi.org/10.1016/j.clinph.2026.2111591
Citations
1
Primary Topic
Pain Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
32.84
Controls
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article

A multicentre randomized double-blind placebo-controlled study of lacosamide, pregabalin, and tapentadol on spinal pain biomarkers

Rolf-Detlef Treede, André Mouraux, Thomas Li, Louisien Lebrun et al.
1 citations
Clinical Neurophysiology
Pain Mechanisms and Treatments
32.84
article

A multicentre randomized double-blind placebo-controlled study of lacosamide, pregabalin, and tapentadol on spinal pain biomarkers

Rolf-Detlef Treede, André Mouraux, Thomas Li, Louisien Lebrun, Luis Garcia-Larrea, Anna V. Kostenko, Charbel Salameh, Andrea Truini, Caterina M. Leone, Nanna B. Finnerup, Solenn Gousset, Bernd Genser, Clarence Rong, Charles Quesada, Giulia di Stefano, Bo Jiang, Giuseppe di Pietro, Niko Möller-Grell, Ombretta Caspani, Caroline Perchet
article en
1 citations

Abstract

Our findings support the RIII threshold as an objective spinal biomarker to assess antihyperalgesic drug effect. This study informs future choices of biomarkers, optimal timing, and analysis strategies in analgesic research.

Clinical Neurophysiology
Université Claude Bernard Lyon 1 (FR), Centre National de la Recherche Scientifique (FR), European Molecular Biology Organization (DE), Inserm (FR), Heidelberg University (DE), Centre de Recherche en Neurosciences de Lyon (FR), Central Institute of Mental Health (DE), Bernstein Center for Computational Neuroscience Heidelberg-Mannheim (DE), Teva Pharmaceuticals (United States) (US), Danish Pain Research Center (DK), Ospedale San Giuseppe (IT), Sapienza University of Rome (IT), Université Jean Monnet (FR), UCLouvain (BE)
Good health and well-being
Openalex Percentile: Top 1%
Pain Mechanisms and Treatments
32.84
DOIOpen Access PDFOpenAlex
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A multicentre randomized double-blind placebo-controlled study of lacosamide, pregabalin, and tapentadol on spinal pain biomarkers — Rolf-Detlef Treede, André Mouraux, et al. · Clinical Neurophysiology (2026) | TGRS Research Map | TGRS