Vortioxetine in Subgroups of Patients with Major Depressive Disorder and Early-Stage Dementia: Further Results from the MEMORY Study

Our findings provide further support for the effectiveness and tolerability of vortioxetine in patients with MDD and early-stage dementia. Clinically significant improvement in depressive symptoms, cognitive performance, and health-related quality of life during treatment with vortioxetine was observed in patients with Alzheimer's disease, those with mixed-type dementia, patients receiving concomitant treatment with drugs for dementia, and those with severe depression.

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Publication Details

Journal
Neuropsychiatric Disease and Treatment
Published
2026-02-01
DOI
https://doi.org/10.2147/ndt.s549106
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
0.00

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article

Vortioxetine in Subgroups of Patients with Major Depressive Disorder and Early-Stage Dementia: Further Results from the MEMORY Study

Simon Schmidt, Elin Reines, Michael Christensen, Iria Grande
Neuropsychiatric Disease and Treatment
Treatment of Major Depression
article

Vortioxetine in Subgroups of Patients with Major Depressive Disorder and Early-Stage Dementia: Further Results from the MEMORY Study

Simon Schmidt, Elin Reines, Michael Christensen, Iria Grande
article en

Abstract

Our findings provide further support for the effectiveness and tolerability of vortioxetine in patients with MDD and early-stage dementia. Clinically significant improvement in depressive symptoms, cognitive performance, and health-related quality of life during treatment with vortioxetine was observed in patients with Alzheimer's disease, those with mixed-type dementia, patients receiving concomitant treatment with drugs for dementia, and those with severe depression.

Neuropsychiatric Disease and TreatmentVol. Volume 22
Lundbeck (Denmark) (DK), Instituto de Salud Carlos III (ES), Centro de Investigación Biomédica en Red de Salud Mental (ES), Hospital Clínic de Barcelona (ES), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), Universitat de Barcelona (ES)
H. Lundbeck A/S
Openalex Percentile: Top 70%
Treatment of Major Depression
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