Hydrogen‐Mediated Activation of the Nrf2/ <scp>HO</scp> ‐1 Signaling Pathway Improves Cognitive Impairment in Sleep‐Deprived Mice

These results indicate that H<sub>2</sub> alleviates oxidative stress and neuroinflammation through Nrf2/HO-1 pathway activation, mitigating SD-induced cognitive impairment. This research provides a theoretical foundation for potential clinical applications.

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Publication Details

Journal
CNS Neuroscience & Therapeutics
Published
2026-02-01
DOI
https://doi.org/10.1002/cns.70770
Primary Topic
Hydrogen's biological and therapeutic effects
Type
article
Field-Weighted Citation Impact
0.00
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article

Hydrogen‐Mediated Activation of the Nrf2/ HO ‐1 Signaling Pathway Improves Cognitive Impairment in Sleep‐Deprived Mice

QiFan Xiao, ShiRui Zhou, YuQing Zhu, Bin Tang
CNS Neuroscience & Therapeutics
Hydrogen's biological and therapeutic effects
article

Hydrogen‐Mediated Activation of the Nrf2/ HO ‐1 Signaling Pathway Improves Cognitive Impairment in Sleep‐Deprived Mice

QiFan Xiao, ShiRui Zhou, YuQing Zhu, Bin Tang
article en

Abstract

These results indicate that H<sub>2</sub> alleviates oxidative stress and neuroinflammation through Nrf2/HO-1 pathway activation, mitigating SD-induced cognitive impairment. This research provides a theoretical foundation for potential clinical applications.

CNS Neuroscience & TherapeuticsVol. 32(2)
Beijing University of Chinese Medicine (CN), China-Japan Friendship Hospital (CN)
Openalex Percentile: Top 70%
Hydrogen's biological and therapeutic effects
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