The interplay between GBA1 status and age of onset on cognitive, motor and non-motor outcomes in Parkinson’s disease: multicenter cross-sectional study
In the first decade of PD, cognitive decline is mainly age and duration dependent, irrespective of GBA1 genotype. Early onset does not increase cognitive risk in GBA-PD, supporting its relevance for counseling and treatment planning.
Authors
- Carlo Alberto Artusi
- Elisa Montanaro
- Francesca Donetto
- Micol Avenali
- Enza Maria Valente
- Valeria Sant’Elia
- Claudia Ledda
- Luisa Sambati
- Marco Bozzali
- Rosa De Micco
- Alessandro Tessitore
- Pierfrancesco Mitrotti
- Silvia Gallo
- Luca Gallo
- Alberto Romagnolo
- Giovanna Calandra-Buonaura
- Gabriele Imbalzano
- Leonardo Lopiano
- Giulia Giannini
- Mattia Siciliano
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- University of Pavia (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Turin (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1007/s00415-026-13639-x
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Biogen
- Celgene
- Allergan
- Avid Radiopharmaceuticals