The Emerging Crisis in Non-Prescribed Ketamine Use: A Rapid Attenuation of Depression in Face of Abuse and “Chill-out” or Escapism Drug

Elucidating ketamine's mechanism of action may inform the development of next-generation psychoplastogens that promote neural plasticity in TRD and unipolar MDD. However, ketamine's psychoactive properties and abuse potential, along with concerns regarding misuse and diversion, underscore the need for enhanced clinical oversight and regulatory frameworks.

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Publication Details

Journal
Substance Use & Misuse
Published
2026-02-01
DOI
https://doi.org/10.1080/10826084.2025.2612330
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
0.00
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article

The Emerging Crisis in Non-Prescribed Ketamine Use: A Rapid Attenuation of Depression in Face of Abuse and “Chill-out” or Escapism Drug

Debasis Bagchi, Morgan P. Lorio, Sergio Schmidt, Mark S. Gold et al.
Substance Use & Misuse
Treatment of Major Depression
article

The Emerging Crisis in Non-Prescribed Ketamine Use: A Rapid Attenuation of Depression in Face of Abuse and “Chill-out” or Escapism Drug

Debasis Bagchi, Morgan P. Lorio, Sergio Schmidt, Mark S. Gold, Rossano Kepler Alvim Fiorelli, Margaret A. Madigan, Alexander P. L. Lewandrowski, Kai Uwe Lewandrowski, Kenneth Blum, Panayotis K. Thanos, David Baron, Albert Pinhasov, Edward J. Modestino, Catherine A. Dennen, Rajendra D. Badgaiyan, Kavya Mohankumar, Alireza Sharafshah
article en

Abstract

Elucidating ketamine's mechanism of action may inform the development of next-generation psychoplastogens that promote neural plasticity in TRD and unipolar MDD. However, ketamine's psychoactive properties and abuse potential, along with concerns regarding misuse and diversion, underscore the need for enhanced clinical oversight and regulatory frameworks.

Substance Use & Misuse
Eötvös Loránd University (HU), Tulane University (US), University of Southern California (US), Texas Tech University (US), Allen Institute for Brain Science (US), Wright State University (US), Guilan University of Medical Sciences (IR), Northeast Health (US), Tula University (RU), Center for Health, Exercise and Sport Sciences (RS), Desert Institute For Spine Care (US), NeuroGenetic Pharmaceuticals (United States) (US), Czech Academy of Sciences, Institute of Psychology (CZ), Advanced Center for Orthopedics (US), Jacobs Institute (US), Institute of Bioinformatics and Applied Biotechnology (IN), Fundación Universitaria Sanitas (CO), Ariel University (IL), Adelphi University (US), Universidade Federal do Estado do Rio de Janeiro (BR), The Chicago School (US), Texas Tech University Health Sciences Center (US), Stanford University (US)
Good health and well-being
Openalex Percentile: Top 70%
Treatment of Major Depression
DOISourceOpenAlex
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