Zhi-Chuan-Ling alleviates OVA-induced allergic asthma by suppressing M2 macrophage polarization via the PI3K/AKT/mTOR/STAT6 pathway
ZCL protects against allergic asthma by suppressing M2 macrophage polarization through the PI3K/AKT/mTOR/STAT6 axis and by directly interacting with key pathway proteins, thereby attenuating airway inflammation and remodeling. These findings provide both functional and molecular evidence for the therapeutic potential of ZCL in allergic asthma.
Authors
- Liping Sun
- Ling Wang
- Jing Han
- Huidan Chen
- Siye Lv
- Jinpu Zhu
- Sihui Xing
- Jicheng Han
- Zhongtian Wang
Institutions
- Changchun University of Chinese Medicine (CN)
- Changchun Children's Hospital (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.phymed.2026.157911
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00