Influence of thrombocytosis on the prognosis of endometrial cancer: Results from propensity score matching

Thrombocytosis has been implicated as a potential prognostic biomarker in various malignancies, but its role in endometrial cancer (EC) remains unclear. This retrospective cohort study evaluated the prognostic value of elevated preoperative platelet count (PLT) in patients with EC. A total of 548 patients treated at Changhua Christian Hospital between 2010 and 2021 were included. Patients were classified into high (>400 × 10⁹/L) and normal PLT groups, and propensity score matching was applied in a 1:3 ratio to balance baseline characteristics. Recurrence, disease-free survival (DFS), and overall survival (OS) were assessed using Kaplan-Meier analysis and Cox proportional hazards modeling. After matching, 224 patients were analyzed. The high PLT group demonstrated significantly higher recurrence (37.5% vs 26.8%), shorter DFS (48.2% vs 67.3%), and reduced OS (71.4% vs 83.3%). Adjusted hazard ratios for high PLT were 1.76 for recurrence, 1.98 for DFS, and 2.11 for OS. These findings suggest that thrombocytosis is an independent prognostic factor in EC and may serve as a useful tool for risk stratification and treatment planning.