Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report

Melatonin is a neurohormone that primarily regulates sleep patterns and circadian rhythms by interacting with melatonin receptors MT1 and MT2. Disruptions in circadian rhythms may contribute to mood disorders; for example, individuals with major depressive disorder often have significantly lower melatonin levels compared to healthy individuals. In this report, we present a patient who experienced a depressed mood and nighttime sleep disturbances and was treated with melatonin. In patients with depression, factors such as insomnia or poor psychosocial conditions can increase the risk of suicidal thoughts.