Bioequivalence of netupitant and palonosetron (NEPA) oral suspension and hard capsules in healthy individuals: results from an open-label, randomized, two-treatment, four-period, two-sequence replicative design trial
The NEPA oral suspension is pharmacokinetically bioequivalent to the capsule formulation in healthy individuals, with no new safety concerns. These findings support NEPA oral suspension as a potentially beneficial option for patients who prefer an oral suspension over a hard capsule and for those with swallowing difficulties. EUCT Number: 2023-504355-28-00 (25/08/2023).
Authors
- Riccardo Bezzo
- Edis Gasanin
- Tulla Spinelli
- Friedeborg Seitz
Institutions
- Clinical Research Services (DE)
- Helsinn (Switzerland) (CH)
Publication Details
- Journal
- Supportive Care in Cancer
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1007/s00520-026-10345-2
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helsinn
- Aptitude Health