Bioequivalence of netupitant and palonosetron (NEPA) oral suspension and hard capsules in healthy individuals: results from an open-label, randomized, two-treatment, four-period, two-sequence replicative design trial

The NEPA oral suspension is pharmacokinetically bioequivalent to the capsule formulation in healthy individuals, with no new safety concerns. These findings support NEPA oral suspension as a potentially beneficial option for patients who prefer an oral suspension over a hard capsule and for those with swallowing difficulties. EUCT Number: 2023-504355-28-00 (25/08/2023).

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Publication Details

Journal
Supportive Care in Cancer
Published
2026-02-01
DOI
https://doi.org/10.1007/s00520-026-10345-2
Primary Topic
Gastroesophageal reflux and treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Bioequivalence of netupitant and palonosetron (NEPA) oral suspension and hard capsules in healthy individuals: results from an open-label, randomized, two-treatment, four-period, two-sequence replicative design trial

Riccardo Bezzo, Edis Gasanin, Tulla Spinelli, Friedeborg Seitz
Supportive Care in Cancer
Gastroesophageal reflux and treatments
article

Bioequivalence of netupitant and palonosetron (NEPA) oral suspension and hard capsules in healthy individuals: results from an open-label, randomized, two-treatment, four-period, two-sequence replicative design trial

Riccardo Bezzo, Edis Gasanin, Tulla Spinelli, Friedeborg Seitz
article en

Abstract

The NEPA oral suspension is pharmacokinetically bioequivalent to the capsule formulation in healthy individuals, with no new safety concerns. These findings support NEPA oral suspension as a potentially beneficial option for patients who prefer an oral suspension over a hard capsule and for those with swallowing difficulties. EUCT Number: 2023-504355-28-00 (25/08/2023).

Supportive Care in CancerVol. 34(2)
Clinical Research Services (DE), Helsinn (Switzerland) (CH)
Helsinn, Aptitude Health
Good health and well-being
Openalex Percentile: Top 70%
Gastroesophageal reflux and treatments
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