Aplicações recentes da microfluídica nas Ciências Farmacêuticas e sua potencial utilidade em conceitos bottom-up de Qualidade por Design

Introduction: Microfluidic science has significantly permeated biomedical sector since the 1990s, today they have potential application in quality-based design of pharmaceutical products using bottom-up approaches. Methodology: In this article, a review of some articles published from 2019 to 2025 is made to show the utility that microfluidics can have in each stage of medicines development. To demonstrate the capabilities of micro systems some examples are summarized, highlighting the qualities that may be attractive from the Quality by Design (QbD) methodology point of view; In order to segment the information, the topics are classified into four groups: medical diagnosis, production of drug delivery systems, drug discovery and organ-on-a-chip technology. Results: Since microfluidics make it possible to produce different types of nanostructured formulations and control their final properties, when increasing the conceptual basis on the mechanisms of diseases and evaluate the effect of drugs when exposed to human cells, it is possible to spread its potential in an integral way to all development phases of pharmaceutical products.