Anulação e melhora da toxicidade do cádmio por meio de medidas dietéticas

Background: Cadmium (Cd) is an environmental toxin that penetrates most parts of the environment and causes significant health hazards when it accumulates in the human body. Chronic Cd exposure, particularly in individuals with metabolic disorders like diabetes, leads to oxidative stress, inflammation, and organ damage. Purpose: This study aimed to establish whether dietary herbs, present in the polluted regions, can neutralize and reverse Cd-induced toxicity. Methodology: Main focus to assess the efficiency of the herbs in reducing Cd toxicity and enhancing biological health indices. Enhydra fluctuans (Lour) is the dietary herb used. Using 20 rats of either sex exposed to Cd and then treated with selected edible herbs known for their detoxifying properties, a controlled laboratory experiment was conducted. Compared to controls, the treated groups' Cd levels significantly decreased, and the related harmful effects improved. Results: E. fluctuans-treatment group showed significant decreases in blood glucose levels and normalization of liver enzymes (AST, ALT, ALP, bilirubin). Kidney function tests showed improvement in serum creatinine, BUN, uric acid, and urine protein levels. Histological studies confirmed preserved cellular architecture of the liver, kidney, and pancreas. Conclusion: E. fluctuans presents potent antidiabetic, antioxidant, hepatoprotective, and nephroprotective effects to help ameliorate systemic toxicity from Cd exposure. Contribution: The finding of the study supports the potential of E. fluctuans as an affordable, natural dietary response to heavy metal contamination, especially in environmentally exposed and metabolically compromised and metabolic stress, as well as providing meaningful contributions to the specific area of herbal toxicology and public health nutrition.