Estudo de compatibilidade de clonazepam e excipientes em formulações farmacêuticas sólidas

This study has had as main objectives to apply the analysis via fourier-transform infrared spectroscopy (FTIR), thermogravimetry (TG), differential scanning calorimetry (DSC) to verify the degradation and alteration of the functional groups of clonazepam, due to their importance as a characterization tools, and to use a validated method for the quantification of clonazepam, with a new chromatographic analysis with no use of buffer in the mobile phase to be applied in the studies of stability of pharmaceutic formulations and in the analysis of degradation products. The results obtained from the thermal analysis have showed that the studied excipients did not reveal changes in the thermal behavior of the binary mixtures, clonazepam excipient, with no indication of incompatibility. The analytic method developed by high performance liquid chromatography (HPLC) has been shown adequate for quantification of clonazepam and its impurities. The implementation of thermal analysis and the application of new analytic methods have been considered important strategies in the diverse areas of the pharmaceutical industry, providing information that define the technological quality parameters of the products, aiming the development of new formulations.