Terapia medicamentosa contra o câncer com derivados de gencitabina com ligante PEG para doenças ginecológicas, além de terapia fonoaudiológica na implementação do cuidado biomédico pós-operatório

Background: Although Gemcitabine is applied for chemotherapy as an important drug for breast, head and neck, lung, bladder, as well as acute lymphocytic leukemia, non-Hodgkin's lymphoma, osteosarcoma, and choroid carcinoma, we found derivatives combination of Gemcitabine enable to increase the effectiveness for cancer treatment significantly and these derivatives drugs can be used for decreasing desmoids tumor in the treatment of aggressive fibromatosis. Aim: Therefore, our goal was based on analyzing of a series of gemcitabine derivatives containing imine structure (G1-G5), which can be synthesized through reaction of gemcitabine with several aromatic aldehydes for this research and any further activities such as drug design or drug delivery. Materials and methods: Furthermore, the structures of the imine derivatives were proved via CHNS/O elemental analysis, FTIR and NMR spectroscopy, which all measurements confirmed the imine derivatives of α-glucosidase inhibition. Results: Compound (G5) exhibited higher therapeutic indices, representing possible promising roles. We used gemcitabine derivatives containing Schiff base structure (G5) for patient that could be lead a new design in this study of novel α-glucosidase inhibitor. Conclusions: surgery disrupts the physiological balance of the human body and causes great stress and changes hormonal, metabolic, immune and nervous functions, using this drug (G5) during recovery after surgery (ERAS) is a multitasking care process that preserves the normal physiological state and reduces surgical complications of surgery