A spectral dimension reduction technique that improves pattern detection in multivariate spatial data

The algorithm is implemented in the open source software R and is available at https://github.com/IMSBCompBio/SpaCo.

Authors

Kiarash Rastegar
Till Baar (ORCID: https://orcid.org/0000-0002-6744-1463)
David Köhler (ORCID: https://orcid.org/0009-0006-0027-4046)
Chrysa Nikopoulou (ORCID: https://orcid.org/0000-0001-7982-7737)
Vangelis Kondylis (ORCID: https://orcid.org/0000-0002-6970-8731)
Achim Tresch (ORCID: https://orcid.org/0000-0002-4146-6371)
Niklas Kleinenkuhnen (ORCID: https://orcid.org/0009-0002-5453-6081)
Peter Tessarz (ORCID: https://orcid.org/0000-0002-6953-9835)
Matthias Schmid
Vlada Milchevskaya

Institutions

University of Cologne (DE)
University Hospital Bonn (DE)
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
University Hospital Cologne (DE)
Max Planck Institute for Biology of Ageing (DE)

Publication Details

Journal: Bioinformatics
Published: 2026-01-28
DOI: https://doi.org/10.1093/bioinformatics/btag052
Primary Topic: Single-cell and spatial transcriptomics
Type: article
Field-Weighted Citation Impact: 0.00

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article

A spectral dimension reduction technique that improves pattern detection in multivariate spatial data

Kiarash Rastegar, Till Baar, David Köhler, Chrysa Nikopoulou et al.

Jan 28, 2026

Bioinformatics

Single-cell and spatial transcriptomics

article

A spectral dimension reduction technique that improves pattern detection in multivariate spatial data

Kiarash Rastegar, Till Baar, David Köhler, Chrysa Nikopoulou, Vangelis Kondylis, Achim Tresch, Niklas Kleinenkuhnen, Peter Tessarz, Matthias Schmid, Vlada Milchevskaya

January 28, 2026article en

Abstract

The algorithm is implemented in the open source software R and is available at https://github.com/IMSBCompBio/SpaCo.

BioinformaticsVol. 42(2)

University of Cologne (DE), University Hospital Bonn (DE), Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE), University Hospital Cologne (DE), Max Planck Institute for Biology of Ageing (DE)

Openalex Percentile: Top 71%

Single-cell and spatial transcriptomics

DOI Open Access PDF OpenAlex

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A spectral dimension reduction technique that improves pattern detection in multivariate spatial data — Kiarash Rastegar, Till Baar, et al. · Bioinformatics (2026) | TGRS Research Map | TGRS