Occurrence, molecular confirmation, and multidrug resistance of methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in companion animals in Indonesia

This study reveals a great burden of methicillin- and multidrug-resistant staphylococci among companion animals with clinical infections in Indonesia. The detection of <i>mecA</i>-positive MRSA and MRSP underscores a substantial zoonotic risk and highlights the limitations of phenotypic methods. These findings emphasize the need for routine molecular diagnostics, strengthened antimicrobial stewardship in veterinary practice, and integrated One Health surveillance to mitigate the spread of AMR across animal-human interfaces.