Unique Bidentate Chelators of Functionalized HeterocyclicFluoroquinolones with Dual Anti-Inflammatory and SelectiveCytotoxic Effects via a C7-C8 Ethylene Diamine Bridge
The mechanism of action of the FQs involved acidic functional groups and a C7-C8 ethylenediamine chelation bridge, with iron chelation being the predominant pathway.
Authors
- Violet Kasabri (ORCID: https://orcid.org/0000-0003-1927-0193)
- Imad I. Hamdan
- Qosay Al‐Balas
- Yusuf Al‐Hiari
- Shereen Arabiyat
- Dalya Alsaad
- Moneera Alzghoul
- Ahmad Telfah
- Mohammad Bashar AlQazzan
Institutions
- University of Jordan (JO)
- Al-Zaytoonah University of Jordan (JO)
- Jordan University of Science and Technology (JO)
- Dortmund University of Applied Sciences and Arts (DE)
- American University of Madaba (JO)
- Alrafidain University College (IQ)
- Al-Balqa Applied University (JO)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-01-28
- DOI
- https://doi.org/10.2174/0109298673338657251018045851
- Citations
- 2
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 44.47