GC-MS Correlated-Antiepileptic Screening For Probable GABA-Modulator By PTZ-Induced Acute Seizure Model In Swiss Albino Mice And Phytochemical Profiling Of Ethanol Extract Of Ficus Benghalensis

The findings suggest that the phytoconstituents of Ficus benghalensis, such as polyphenols, flavonoids, sterols and previously unidentified alkaloids, play a key role in mitigating oxidative stress, neuroinflammation and GABAergic dysfunction associated with epilepsy, which demonstrates its potential as a source of lead compound for new antiepileptic drugs. Detailed investigations on isolated phytochemicals can be done to explore their antiepileptic potential.

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Publication Details

Journal
Pakistan Journal of Pharmaceutical Sciences
Published
2026-01-28
DOI
https://doi.org/10.36721/pjps.2026.39.3.reg.14501.1
Primary Topic
Phytochemistry and biological activities of Ficus species
Type
article
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article

GC-MS Correlated-Antiepileptic Screening For Probable GABA-Modulator By PTZ-Induced Acute Seizure Model In Swiss Albino Mice And Phytochemical Profiling Of Ethanol Extract Of Ficus Benghalensis

Md. Mohaimenul Islam, Sulaman Yaqub, Abrar Ahmad, Hamid Saeed
Pakistan Journal of Pharmaceutical Sciences
Phytochemistry and biological activities of Ficus species
article

GC-MS Correlated-Antiepileptic Screening For Probable GABA-Modulator By PTZ-Induced Acute Seizure Model In Swiss Albino Mice And Phytochemical Profiling Of Ethanol Extract Of Ficus Benghalensis

Md. Mohaimenul Islam, Sulaman Yaqub, Abrar Ahmad, Hamid Saeed
article en

Abstract

The findings suggest that the phytoconstituents of Ficus benghalensis, such as polyphenols, flavonoids, sterols and previously unidentified alkaloids, play a key role in mitigating oxidative stress, neuroinflammation and GABAergic dysfunction associated with epilepsy, which demonstrates its potential as a source of lead compound for new antiepileptic drugs. Detailed investigations on isolated phytochemicals can be done to explore their antiepileptic potential.

Pakistan Journal of Pharmaceutical SciencesVol. 39(3)
University of the Punjab (PK)
Good health and well-being
Openalex Percentile: Top 71%
Phytochemistry and biological activities of Ficus species
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