Recent Advances in Synthesis and Applications of 2-Aminobenzothiazole Derivatives

Abstract:: 2-Aminobenzothiazole represents a versatile class of heterocyclic compounds that is composed of a fused benzene ring and a thiazole ring. In recent years, benzothiazole derivatives have garnered considerable attention for research and development due to their broad spectrum of pharmacological properties. Owing to their strong pharmacological activity and wide range of applications, synthetically accessible and adaptable 2- aminobenzothiazole scaffolds are very intriguing in the fields of biology and synthetic organic chemistry. Benzothiazole moiety-containing analogs possess significant antimicrobial, antiviral, anti-inflammatory, antidiabetic, anticancer, antimalarial, antitubercular, anticonvulsant, antiasthmatic, diuretic, analgesic, and anthelmintic activities. Research on the pharmaceutical properties of benzothiazole derivatives remains a fascinating area with potential for discovering novel drugs or treatments. The promising medicinal properties of benzothiazoles and their derivatives have prompted medicinal chemists to develop numerous new therapeutic agents, thereby driving the development of efficient and innovative synthetic approaches. This review focuses on the numerous methods of synthesis and reactions of 2-aminobenzothiazoles and their derivatives that have been utilized over the period 2010-2025, to encourage further research and innovation in the development of novel compounds with a range of applications in drug discovery and other fields.