Single-cell and Mendelian analyses reveal shared mechanisms between head and neck neoplasms and aging
This study identified CD4_naive T cells down-regulation as a shared feature of HNN and aging and highlighted FHIT as potential molecular links. These findings may provide novel insights into the intersection of aging and tumorigenesis based on MR and single-cell analysis, offering potential targets for combined therapeutic strategies.
Authors
- Xinlei Chen (ORCID: https://orcid.org/0000-0001-8271-5023)
- Jinzhao Li (ORCID: https://orcid.org/0009-0008-2953-1928)
- Canli Wang
- Chen Sun
- Lirong Hu
- Rui Shi
- Chunhui Li
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1007/s12672-026-04550-y
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Southwest Medical University