FORMULATION AND EVALUATION OF ORAL MEDICATED JELLY

The present study focuses on the formulation and evaluation of an oral medicated jelly containing glibenclamide, an antidiabetic drug used in the management of Type 2 diabetes mellitus. Oral medicated jellies are patient-friendly dosage forms particularly suitable for pediatric, geriatric, and dysphagic patients due to ease of administration and improved palatability. Glibenclamide oral jellies were prepared using varying concentrations of guar gum and pectin as gelling agents. The prepared formulations were evaluated for physical appearance, viscosity, pH, syneresis, drug content, in vitro drug release, and stability. Among the six formulations, batch F5 demonstrated optimal physicochemical properties, acceptable viscosity, absence of syneresis, uniform drug content, satisfactory drug release, and good stability under different storage conditions. The results suggest that oral medicated jelly is a promising alternative delivery system for glibenclamide, offering improved patient compliance and therapeutic effectiveness.