Exploring Causal Effects of Sarcopenia on Chronic Obstructive Pulmonary Disease and Hospitalization Risk: A Bi-Directional Mendelian Randomization Study

Our study supported a unidirectional, negative causality between sarcopenia-related traits and COPD and hospitalization risk. This provides possible evidence that sarcopenia increases the risk of COPD and hospitalization at the genetic level. Our findings suggest that improving sarcopenia may serve as a promising strategy for minimizing the incidence of COPD and hospitalization risk, thereby reducing the health burden on these patients.