Stool-based SDC2/SFRP2/TFPI2 methylation assay for colorectal neoplasia screening: a multicenter, case-control study
The combined methylation assay of SDC2, SFRP2, and TFPI2 outperformed FOBT and CEA in detecting CRC and AA, although further optimization is required for AA detection. Its high specificity and compatibility with routine screening procedures underscore its potential as a tool for detecting colorectal neoplasia.
Authors
- M. G. Holmes (ORCID: https://orcid.org/0000-0002-0273-0483)
- Kaiyu Li (ORCID: https://orcid.org/0000-0002-8015-6245)
- Jie Pan (ORCID: https://orcid.org/0000-0001-9240-2039)
- Zhiguo Xiong
- Jing Yan
- Qiuyu Liao
- Gang Liu
- Wenhui Yang
Institutions
- University of Cambridge (GB)
- Wenzhou Medical University (CN)
- Tianjin Medical University General Hospital (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Hubei Cancer Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fonc.2026.1748759
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00