Lower FEV <sub>1</sub> and gram-negative bacilli isolation as independent risk factors for exacerbations in post-TB bronchiectasis

<sec><title>BACKGROUND</title>Post-TB bronchiectasis is a recognised but under-investigated category of bronchiectasis. This study evaluated its clinical features and identified risk factors for acute exacerbations (AEs).</sec><sec><title>METHODS</title>This retrospective observational cohort study analysed data from the Taiwan Bronchiectasis Registry. Patients with bronchiectasis were included, and those with post-TB bronchiectasis were identified for subgroup analysis. We collected demographics, symptoms, lung function, microbiological data, and modified Reiff scores to assess risk factors for AEs.</sec><sec><title>RESULTS</title>A total of 1,444 patients were analysed, including 222 (15%) with post-TB bronchiectasis. Among them, 54 (24%) experienced at least one AE during the study period. Post-TB bronchiectasis patients had more frequent AEs, higher FACED and modified Reiff scores, lower body mass index (BMI) and forced expiratory volume in 1 s (FEV<sub>1</sub>), and more symptoms than non-post-TB cases. Post-TB bronchiectasis patients with AEs had higher FACED and Reiff scores, lower BMI and FEV<sub>1</sub>, and higher rates of positive sputum cultures for gram-negative bacilli (GNB). Multivariable analysis identified FEV<sub>1</sub> ≤ 60% predicted (adjusted odds ratio [aOR]: 2.334, 95% CI: 1.192-4.572) and positive GNB cultures (aOR: 3.075, 95% CI: 1.362-6.942) as independent risk factors for AEs.</sec><sec><title>CONCLUSION</title>Post-TB bronchiectasis is associated with a higher risk of exacerbations. Reduced FEV<sub>1</sub> and positive GNB cultures are independent risk factors for AEs.</sec>.

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Publication Details

Journal
The International Journal of Tuberculosis and Lung Disease
Published
2026-01-30
DOI
https://doi.org/10.5588/ijtld.25.0336
Primary Topic
Cystic Fibrosis Research Advances
Type
article
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article

Lower FEV 1 and gram-negative bacilli isolation as independent risk factors for exacerbations in post-TB bronchiectasis

W T Hsu, Y T Wang, C.-Y. Wang, Y. WANG et al.
The International Journal of Tuberculosis and Lung Disease
Cystic Fibrosis Research Advances
article

Lower FEV 1 and gram-negative bacilli isolation as independent risk factors for exacerbations in post-TB bronchiectasis

W T Hsu, Y T Wang, C.-Y. Wang, Y. WANG, P Wang, S. C. CHEN, H.-C. Wang, Chen Lan, M H Hsieh, Yuehua Chen, W-F. Ou, J-Y Chien, C-H. Lin, H-C Lin, Y.-F. Wei, C.-C. Sheu, C-H. Chu, C-B Lin, M-T Chen, M-S Lin, T-M Yang, Y-H Tsai, W-C Cheng, M-C Chan, S-F Liu, C-Y Chen, C-L Chang, M-H Cheng, Y-H Wang, S-L Cheng, C-K Peng, L-Y Jao
article en

Abstract

<sec><title>BACKGROUND</title>Post-TB bronchiectasis is a recognised but under-investigated category of bronchiectasis. This study evaluated its clinical features and identified risk factors for acute exacerbations (AEs).</sec><sec><title>METHODS</title>This retrospective observational cohort study analysed data from the Taiwan Bronchiectasis Registry. Patients with bronchiectasis were included, and those with post-TB bronchiectasis were identified for subgroup analysis. We collected demographics, symptoms, lung function, microbiological data, and modified Reiff scores to assess risk factors for AEs.</sec><sec><title>RESULTS</title>A total of 1,444 patients were analysed, including 222 (15%) with post-TB bronchiectasis. Among them, 54 (24%) experienced at least one AE during the study period. Post-TB bronchiectasis patients had more frequent AEs, higher FACED and modified Reiff scores, lower body mass index (BMI) and forced expiratory volume in 1 s (FEV<sub>1</sub>), and more symptoms than non-post-TB cases. Post-TB bronchiectasis patients with AEs had higher FACED and Reiff scores, lower BMI and FEV<sub>1</sub>, and higher rates of positive sputum cultures for gram-negative bacilli (GNB). Multivariable analysis identified FEV<sub>1</sub> ≤ 60% predicted (adjusted odds ratio [aOR]: 2.334, 95% CI: 1.192-4.572) and positive GNB cultures (aOR: 3.075, 95% CI: 1.362-6.942) as independent risk factors for AEs.</sec><sec><title>CONCLUSION</title>Post-TB bronchiectasis is associated with a higher risk of exacerbations. Reduced FEV<sub>1</sub> and positive GNB cultures are independent risk factors for AEs.</sec>.

The International Journal of Tuberculosis and Lung DiseaseVol. 30(2)
Fu Jen Catholic University (TW), Tri-Service General Hospital (TW), Chang Gung University of Science and Technology (TW), Kaohsiung Medical University (TW), National Chung Hsing University (TW), China Medical University (TW), Tzu Chi University (TW), Tzu Chi Foundation (TW), Taichung Veterans General Hospital (TW), Kaohsiung Chang Gung Memorial Hospital (TW), Taipei Tzu Chi Hospital (TW), Far Eastern Memorial Hospital (TW), Chung Shan Medical University Hospital (TW), Linkou Chang Gung Memorial Hospital (TW), Hualien Tzu Chi Medical Center (TW), China Medical University Hospital (TW), National Taiwan University Hospital (TW), Chiayi Chang Gung Memorial Hospital (TW), Changhua Christian Hospital (TW), National Defense Medical Center (TW), I-Shou University (TW)
Openalex Percentile: Top 72%
Cystic Fibrosis Research Advances
DOISourceOpenAlex
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