Rewriting the RNA code: an m6a-centric framework to classify tumors and guide combination therapies
Targeting the m<sup>6</sup>A epitranscriptome represents a paradigm shift in oncology; our framework provides the essential strategic approach needed to overcome context-dependency, offering a logical structure for tumor classification, vulnerability prediction, and the translation of epitranscriptomic insights into patient benefit through personalized, biomarker-guided combination therapies.
Authors
- Hongyu Tan (ORCID: https://orcid.org/0000-0002-8077-8167)
- Yi Sun (ORCID: https://orcid.org/0000-0003-2024-3459)
- Jinliang Wu
- Haojun Ma
- Kerong Yang
- Guanhao Chen
- Wenshuya Li
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fimmu.2026.1749911
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation