Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early‐onset sleep disruption in AD‐like amyloidogenic mice
These findings identify LC hyperexcitability as a mechanistic driver of early sleep disruption in AD and implicate α2A receptors and Kv7 channels as promising therapeutic targets for early intervention.
Authors
- Yuchen Zhang (ORCID: https://orcid.org/0000-0001-5615-0946)
- Xueting Zhang (ORCID: https://orcid.org/0000-0002-0003-0475)
- Kai‐Wen He
- Mao‐Qing Huang
- Zi‐Yue Zhou
- Peng‐Yue Chen
Institutions
- Shanghai University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1002/alz.71127
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00