Mapping cellular vulnerability in Parkinson’s disease using retro-AAVs and preformed α-synuclein fibrils
αSyn pathology propagates along anatomical pathways, but cell-autonomous factors determine if a neuron exposed to misfolded αSyn will develop Lewy-like pathology or not.
Authors
- Leo Dietrich
- Marco B. Rust (ORCID: https://orcid.org/0000-0003-2737-1250)
- David L. Wokosin (ORCID: https://orcid.org/0000-0002-5497-6944)
- Sharof Khudayberdiev (ORCID: https://orcid.org/0000-0003-0349-116X)
- Martin T. Henrich (ORCID: https://orcid.org/0000-0001-8295-4884)
- Fanni F. Geibl (ORCID: https://orcid.org/0000-0002-5480-0463)
- Helena Kern Wolter
- Ahmed A. S. Musa
- Ted M. Dawson
- Wolfgang H. Oertel
- D. James Surmeier
- Valina L. Dawson
- Rong Chen
Institutions
- Northwestern University (US)
- Johns Hopkins University (US)
- Philipps University of Marburg (DE)
- Justus-Liebig-Universität Gießen (DE)
- Johns Hopkins Medicine (US)
- Brain (Germany) (DE)
- Research Network (United States) (US)
- Phillips University (US)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s40035-026-00535-7
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Philipps-Universität Marburg
- Alzheimer Forschung Initiative
- Deutsche Forschungsgemeinschaft