Antibiofilm Activity of Hemolymph Lectins from the Bivalve Mollusk Glycymeris yessoensis

The antibiofilm activity of two lectins from the hemolymph of the bivalve mollusk Glycymeris yessoensis (GYL and GYL-R) against opportunistic bacteria, Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, was studied for the first time. Lectins significantly suppressed the formation of biofilms of both S. aureus and E. coli. The most pronounced effect for GYL was demonstrated against S. aureus, and for GYL-R against E. coli, which is determined by the carbohydrate specificity of the antibacterial action of these lectins. In addition, GYL and GYL-R caused partial destruction of already formed biofilms by interacting with the exopolysaccharide matrix that forms the basis of bacterial biofilms.