Direct targeting of STAT3 by xanthatin suppresses allergic airway inflammation via inhibition of TSLP release and NK2 cell polarization
Xanthatin ameliorates allergic airway inflammation by directly targeting STAT3, thereby dually inhibiting the TSLP/STAT3 axis in epithelial cells and the subsequent STAT3-dependent differentiation of pathogenic NK2 cells, presenting a promising multi-targeted strategy for asthma treatment.
Authors
- Min Hong (ORCID: https://orcid.org/0000-0002-2086-8937)
- Siqi Wang (ORCID: https://orcid.org/0000-0001-6136-2492)
- Lu Yao (ORCID: https://orcid.org/0009-0006-4563-720X)
- Jie Zheng
- Xiaotong Wang
- Weiyuan Yuan
- Kaifan Bao
- Yanyan Chen
- Yijing Zhou
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1016/j.jep.2026.121296
- Primary Topic
- Polysaccharides Composition and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00