Discovery of Diverse Esterified <i>seco</i> -Polycyclic Polyprenylated Acylphloroglucinols from Two Species of <i>Hypericum</i> Linn. and Their Lipid-Lowering Effect
Hyperesternoids A-K (<b>1-11</b>, respectively), 11 unique esterified <i>seco</i>-PPAPs (<i>seco</i>-polycyclic polyprenylated acylphloroglucinols) with three types of scaffold systems, 5/6 bicyclic (<b>1-3</b>), 5/7/6 tricyclic (<b>4-6</b>), and 5/6/6 tricyclic (<b>7-11</b>), were isolated from two plants of the <i>Hypericum</i> genus. Notably, crystalline mate and chemical transformation methods provided several practical strategies for the elucidation of <i>seco</i>-PPAPs with complex and variable structures. Biologically, the PPARα agonistic activities of all isolates were evaluated via the dual-luciferase reporter assay, and their lipid-lowering effects were studied.
Authors
- Yulu Xie (ORCID: https://orcid.org/0000-0003-0621-7748)
- Mohammad Mahmoud Nagdy (ORCID: https://orcid.org/0000-0001-6085-2860)
- Liao Zhi-hua
- Lingjiang Zeng
- Xue Wang (ORCID: https://orcid.org/0009-0002-1823-4086)
- Fancheng Meng
- Zhaoyue Dong
- Kun Wu
- Honghong Zhan
- Min Chen
- Dan Li
Institutions
- Southwest University (CN)
- National Research Centre (EG)
- All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (RU)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1021/acs.orglett.5c05350
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00