Modulation of LPS-associated virulence activity for reduction of periodontal inflammatory burden
Modulating LPS-associated virulence activity substantially reduces the inflammatory potential of saliva and subgingival plaque. LL-37 and Polymyxin B illustrate complementary strategies for LPS modulations and highlight the feasibility of their use as adjunctive approaches for the prevention and treatment of periodontal diseases.
Authors
- Svetislav Zarić (ORCID: https://orcid.org/0000-0003-4127-0253)
- Susanna Paju (ORCID: https://orcid.org/0000-0002-2048-3420)
- Anbo Dong (ORCID: https://orcid.org/0009-0003-9196-7128)
- Markku Lehto
- Jukka Putaala
Institutions
- University of Helsinki (FI)
- King's College London (GB)
- Helsinki University Hospital (FI)
- Finland University (FI)
- Folkhälsans Forskningscentrum (FI)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fmicb.2026.1728315
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Suomen Lääketieteen Säätiö
- King's College London
- China Scholarship Council
- Suomen Hammaslääkäriseura Apollonia
- Sigrid Juséliuksen Säätiö
- Medical Research Council
- Engineering and Physical Sciences Research Council