Integrated analysis of single-cell and bulk transcriptomes reveals the prognostic value of polyamine metabolism biomarkers and immune microenvironment features in gastric cancer
Polyamine metabolism shapes both cellular heterogeneity and the immune microenvironment in gastric cancer. Our integrated model may provide potential guidance for prognostic stratification and therapeutic decision-making in clinical oncology.
Authors
- Yihan Chen (ORCID: https://orcid.org/0009-0006-4496-4364)
- Qinqin Hu
- Kailun Chen
- Jie Zheng
- Yanan Liu
Institutions
- Shandong University (CN)
- Tongde Hospital of Zhejiang Province (CN)
- Shaoxing No.6 People's Hospital (CN)
- Weihai Municipal Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1658975
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00