First identification and molecular characterization of CTX-M-15 extended-spectrum β-lactamase and OXA-9 β-lactamase in <i>Haemophilus influenzae</i> in the Iberian Peninsula
We describe, for the first time, the presence and characterization of CTX-M-15 and OXA-9 in two <i>Haemophilus influenzae</i> strains: PTHi-14525 (CTX-M-15) from Portugal and HUB-HI042681 (OXA-9) from Spain. Multidrug-resistant PTHi-14525 carried <i>bla</i><sub>CTX-M-15</sub> (two copies) and <i>bla</i><sub>TEM-1</sub> in an ICE<i>HpaHUB5-like</i> element. HUB-HI042681, resistant to β-lactams and aminoglycosides, carried a novel ICE<i>HinHUB1</i>. These findings highlight the genomic plasticity and expanded resistome of <i>H. influenzae</i>, raising concerns about treatment and emphasizing the need for continuous genomic surveillance.
Authors
- Sara Lia Duarte
- Carmen Ardanuy (ORCID: https://orcid.org/0000-0003-0225-607X)
- M. Bessa Pinto
- Paula Bajanca-Lavado
- Irene Cadenas-Jiménez
- M. Manuela Ribeiro
- Sara Martí
- Aida González-Díaz
Institutions
- Hospital de São João (PT)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- National Institute of Health Dr. Ricardo Jorge (PT)
- Medical Research Network (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1128/aac.01649-25
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00