DAPK2 Regulates PKM2 Phosphorylation at Threonine 45 to Facilitate Disturbed Flow-Induced Atherosclerosis
DAPK2-driven phosphorylation of PKM2 at threonine 45 orchestrates endothelial inflammatory responses to disturbed flow, identifying a novel mechanistic axis and potential therapeutic target in atherosclerosis.
Authors
- Yixin Chen (ORCID: https://orcid.org/0000-0002-1545-9004)
- Yuan Zhou (ORCID: https://orcid.org/0000-0002-1393-5476)
- Andrew Howard Baker (ORCID: https://orcid.org/0000-0003-1441-5576)
- Wenjia Ai (ORCID: https://orcid.org/0000-0002-5375-4557)
- Lu Lu (ORCID: https://orcid.org/0000-0002-4815-0724)
- Wang Li (ORCID: https://orcid.org/0000-0002-7207-3837)
- Yuting Zhang (ORCID: https://orcid.org/0000-0002-2547-8831)
- Yulin Zhao (ORCID: https://orcid.org/0000-0003-1266-6056)
- Shuai Guo (ORCID: https://orcid.org/0000-0002-0417-5516)
- Jiangyun Luo
- Yuqing Huo (ORCID: https://orcid.org/0000-0001-9847-0120)
- Runfa Yu
- Kaixiang Cao
- Litao Wang
- Yiming Xu
- Jun He
- Long Xu
Institutions
- City University of Hong Kong (HK)
- Baylor College of Medicine (US)
- Guangdong Pharmaceutical University (CN)
- Peking University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Jiangxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Guangzhou Medical University (CN)
- University of Edinburgh (GB)
Publication Details
- Journal
- Circulation
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1161/circulationaha.125.075951
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00