Pharmacological STING Activation Enhances Autophagy-Mediated Clearance of Mycobacterium tuberculosis in Human Macrophages
Activating the STING pathway with ADU-S100 is a potent host-directed strategy to bolster macrophage autophagy and enhance the elimination of intracellular Mtb. This provides a strong rationale for exploring STING agonists as a novel therapeutic intervention for tuberculosis, addressing a significant and clinically relevant challenge in infectious disease.
Authors
- Junwen Wang (ORCID: https://orcid.org/0000-0002-7379-3692)
- Xiyong Dai
- Feifei Pu (ORCID: https://orcid.org/0000-0002-9174-8780)
- Fei Niu
- Ping Xia
- Jing Feng
- Ronghao Zhong
Publication Details
- Journal
- Journal of Innate Immunity
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1159/000550530
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00