Diagnostic Significance of Aspartate Transaminase and Alanine Transaminase in Hepatitis C Patients

Background: Hepatitis C infection is spreading worldwide at an alarming rate. Hepatitis C is a viral infection that affects the liver. It is caused by the hepatitis C virus and can lead to liver damage, cirrhosis, and even liver cancer if left untreated. The virus is usually spread through contact with infected blood, such as through sharing needles or receiving a blood transfusion, antiviral medications can be used to treat the infection. AST (aspartate aminotransferase) and ALT (alanine aminotransferase) are enzymes that are primarily found in liver cells. The present study aimed to assess the relationship between liver enzymes aspartate transaminase and alanine transaminase with hepatitis c patients. Methods: Patients serums of 40 HCV positive was taken out and 40 healthy HCV negative as controlling groups and examined for ALT and AST analytical measurement. Cross-sectional study was directed from December 2022 to March 2023 in Thi-Qar government, Iraq. Results: Participants age ranged between ≥15 to ≤ 75 years, AST have increased levels in HCV patients as compared to ALT as compared with controlling group. study gender-based shows an increased level of both the enzymes ALT and AST in females as compared to males .age-based study concluded ALT and AST have a non-significant level in age groups > 49 Years in HCV patients Conclusion: study gender-based shows an increased level of both the enzymes ALT and AST in females as compared to males. Moreover, gender-based study concluded ALT and AST have a non-significant level in age groups > 49 Years in HCV patients AST have increased levels in HCV patients as compared to ALT indicating AST to be more specific biomarker of HCV infection and liver damage.