Pathophysiology of Chronic Pain

Synthesising cross-disciplinary evidence positions chronic pain as a systems disease requiring integrated, mechanism-based and person-centred care. Defining the shared biological scaffold clarifies why traditional symptom-focused treatments fail and outlines research priorities for disease-modifying analgesics and equitable delivery models.

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Publication Details

Journal
Clinical Journal of Pain
Published
2026-01-02
DOI
https://doi.org/10.1097/ajp.0000000000001362
Primary Topic
Pain Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Pathophysiology of Chronic Pain

Stanley Lyndon
Clinical Journal of Pain
Pain Mechanisms and Treatments
article

Pathophysiology of Chronic Pain

Stanley Lyndon
article en

Abstract

Synthesising cross-disciplinary evidence positions chronic pain as a systems disease requiring integrated, mechanism-based and person-centred care. Defining the shared biological scaffold clarifies why traditional symptom-focused treatments fail and outlines research priorities for disease-modifying analgesics and equitable delivery models.

Clinical Journal of Pain
Brigham and Women's Hospital (US), Harvard University (US)
Openalex Percentile: Top 71%
Pain Mechanisms and Treatments
DOISourceOpenAlex
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Pathophysiology of Chronic Pain — Stanley Lyndon · Clinical Journal of Pain (2026) | TGRS Research Map | TGRS