The predictive value of MR cytometry in histological differentiation of rectal cancer: an exploratory study
Question Microstructural parameters obtained from MR cytometry methods and apparent diffusion coefficients showed significant differences between rectal tumors with different histological differentiation grades. Findings The combined regression models, including both microstructural parameters and apparent diffusion coefficient metrics, provided a significantly higher value than the conventional PGSE-based ADC measurement. Clinical relevance Incorporating transcytolemmal water exchange into biophysical modeling can further improve the clinical performance over the impermeable model.
Authors
- Chaoyang Jin (ORCID: https://orcid.org/0000-0002-9749-8962)
- Thorsten Feiweier (ORCID: https://orcid.org/0009-0005-3537-9844)
- Diwei Shi (ORCID: https://orcid.org/0000-0001-8261-4943)
- Junzhong Xu (ORCID: https://orcid.org/0000-0001-7895-4232)
- Zheng Wang (ORCID: https://orcid.org/0000-0003-4873-505X)
- yueluan jiang
- Zhuo Shi
- Qing Zhao
- Hongmei Zhang
- Bingjing Wang
- Hua Guo
- Hongxia Zhong
- Lin Li
Institutions
- Siemens (Germany) (DE)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Forestry University (CN)
- National Cancer Center (US)
- Shanxi Provincial Cancer Hospital (CN)
- Tsinghua–Berkeley Shenzhen Institute (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Siemens Healthcare (United States) (US)
- Siemens Healthineers (Germany) (DE)
- Vanderbilt University Medical Center (US)
- Tsinghua University (CN)
Publication Details
- Journal
- European Radiology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1007/s00330-026-12341-w
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation