Evidence Maps of Vasopressor Use in Adult Patients With Septic Shock: An Umbrella Review

Current evidence fails to demonstrate superior efficacy of alternative vasoactive agents compared to norepinephrine across all evaluated outcome indicators. Considering both the reduced risk of arrhythmias and the increased risk of digital ischemia associated with vasopressin, clinicians should individualize therapy based on patient-specific factors. In addition, our evidence maps identify gaps in the existing literature, highlighting areas for future research.