Expanding the Genetic Landscape of Congenital Insensitivity to Pain

These data broaden the genetic spectrum of CIP and reinforce <i>PRDM12</i> as a key gene in pain perception. They also emphasize that diagnostic analysis should target both single-nucleotide variants and polyalanine expansions, which are often underrepresented in whole-exome or whole-genome sequencing data.

Authors

Oranee Sanmaneechai (ORCID: https://orcid.org/0000-0002-4557-0387)
Pimchanok Kulsirichawaroj (ORCID: https://orcid.org/0000-0002-9406-8481)
Numpueng Ridchuayrod
Theeraphong Pho-iam
Chanin Limwongse
Stephan Zuchner
Surachai Likasitwattanakul

Institutions

Siriraj Hospital (TH)
Mahidol University (TH)
University of Miami Health System (US)

Publication Details

Journal: Neurology Genetics
Published: 2026-02-01
DOI: https://doi.org/10.1212/nxg.0000000000200346
Primary Topic: Pain Management and Opioid Use
Type: article
Field-Weighted Citation Impact: 0.00

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article

Expanding the Genetic Landscape of Congenital Insensitivity to Pain

Oranee Sanmaneechai, Pimchanok Kulsirichawaroj, Numpueng Ridchuayrod, Theeraphong Pho-iam et al.

Feb 1, 2026

Neurology Genetics

Pain Management and Opioid Use

article

Expanding the Genetic Landscape of Congenital Insensitivity to Pain

Oranee Sanmaneechai, Pimchanok Kulsirichawaroj, Numpueng Ridchuayrod, Theeraphong Pho-iam, Chanin Limwongse, Stephan Zuchner, Surachai Likasitwattanakul

February 1, 2026article en

Abstract

These data broaden the genetic spectrum of CIP and reinforce <i>PRDM12</i> as a key gene in pain perception. They also emphasize that diagnostic analysis should target both single-nucleotide variants and polyalanine expansions, which are often underrepresented in whole-exome or whole-genome sequencing data.

Neurology GeneticsVol. 12(1)

Siriraj Hospital (TH), Mahidol University (TH), University of Miami Health System (US)

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Pain Management and Opioid Use

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