Photochemical Amination of Thioethers Under Biphasic Flow Conditions

A practical, continuous flow, biphasic photochemical amination of thioethers, employing N ‐mesyloxycarbamates as nitrene precursors, is reported. Using UVA irradiation at 365 nm and Fe(acac) 3 as a catalyst, the reaction efficiently converts aromatic and aliphatic thioethers into Troc‐protected sulfilimines in high yields. The biphasic ethyl acetate/water system plays a critical role in preventing clogging of the reactor by dissolving the mesylate byproduct.