Comprehensive tumour‐immune profiling reveals TREM2 <sup>+</sup> tumour‐associated macrophages facilitating lymph node metastasis in head and neck squamous cell carcinoma
This study delineates the mechanism that TREM2<sup>+</sup> TAMs promote LN metastasis in HNSCC by facilitating CD8<sup>+</sup> T cells exhaustion via SPP1-CD44-BHLHE40 axis, proposing TREM2<sup>+</sup> TAMs as potential therapeutic target for HNSCC.
Authors
- C. Cheng
- Sien Zhang
- Z Li
- Minyi Ren
- Hanhao Zheng (ORCID: https://orcid.org/0009-0003-2790-5061)
- Hongxi Cao
- Zhuokai Wu
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Yixi Wang
- Lixian Wu
- Tingyi Lee
- Weijie Huang
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Stomatology Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1002/ctm2.70604
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- National Postdoctoral Program for Innovative Talents