Glutathione responsive iNOS inhibiting polymeric prodrug for targeted Inhibition of angiogenesis
This is the first report of a GSH-responsive polymeric prodrug system that leverages intracellular GSH for both controlled release of anionic therapeutic agents and in situ synthesis of an iNOS antagonist. Through these two complementary pathways, the system enables targeted, sustained anti-angiogenic effects and promotes vascular normalization. This dual-function platform holds strong potential for the treatment of cancer-associated angiogenesis.
Authors
- Houman Alimoradi (ORCID: https://orcid.org/0000-0002-2317-5538)
- Laurence Dewachter (ORCID: https://orcid.org/0000-0002-0452-1861)
- Françoise Grégoire (ORCID: https://orcid.org/0000-0003-0452-8868)
- Nargis Bolaky
- Pascale Jespers
- Armin Shavandi (ORCID: https://orcid.org/0000-0002-0188-3090)
- Anita Fallah
- Susanna Törnroth-Horsefield
- Christine Delporte
- Helen Townley
Institutions
- Université Libre de Bruxelles (BE)
- Lund University (SE)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1186/s12951-026-04022-z
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00