Role of Specific miRNA Expression and Nuclear Kappa B Gene Polymorphism as Potential Diagnostic Markers for Chronic Myeloid Leukemia
miR-21 is elevated in CML patients, suggesting an oncogenic role. Our results suggest that miR-302 may serve as a prognostic and diagnostic biomarker. The NF-κB1 gene rs28362491 Del/Del genotype may be associated with an increased risk of CML. Identification of these biomarkers can contribute significantly to improve both diagnosis and treatment strategies.
Authors
- Issa Dababneh
- Moath Alqaraleh (ORCID: https://orcid.org/0000-0003-2072-2441)
- Dana A. Alqudah (ORCID: https://orcid.org/0000-0002-6127-2259)
- Nirmeen Elzogheir
- Jehad Alhmoud
- Sarah N. Dala-Ali
- Nada L. Odeh
- Futoon Abedrabbu Al-Rawashdea
- Leen S. Alhiary
Publication Details
- Journal
- Medical Principles and Practice
- Published
- 2026-01-30
- DOI
- https://doi.org/10.1159/000550722
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Jordan
- Al-Ahliyya Amman University