Prostaglandin E₂ Reverses Myofibroblast Differentiation in Eosinophilic Esophagitis
PGE<sub>2</sub> promotes dedifferentiation of myofibroblasts in EoE via the cAMP/YAP/THBS-1 pathway. Our data suggest that PGE<sub>2</sub> is a promising treatment strategy for EoE with stenosis.
Authors
- D. Dhakal (ORCID: https://orcid.org/0009-0001-2034-3938)
- Takefumi Itami
- Archana Anandakrishnan
- Benjamin J. Wilkins (ORCID: https://orcid.org/0000-0002-1797-7323)
- Chizoba N. Umeweni
- Mark Mahon
- Masaru Sasaki (ORCID: https://orcid.org/0000-0002-6618-2586)
- A M Muir
- Yusen Zhou
- Heidi Winters
- Ryugo Teranishi
- Grace Davis
- Emily McMillan
- Bella Peterson
- Tatiana Karakasheva
- Kanak V Kennedy
- Reness Lee
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
- Temple University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-29
- DOI
- https://doi.org/10.64898/2026.01.27.702012
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00